Temporal Design Assessment

1About You

Your information is kept confidential and used only to deliver your assessment.

First Name *

Last Name *

Title / Position

Company / Institution *

Work Email *

2Study Overview

General study characteristics. No compound or target identification needed.

Privacy note: We do not ask for your compound name, molecular target, mechanism of action, or proprietary biomarker identities. The temporal design assessment only requires information about when and what type of measurements are taken.

Study Phase *

Therapeutic Area *

Indication Detail

Optional — helps us benchmark against similar trials

Planned Enrollment

Study Duration

Number of Sites

Primary Region

3Measurement Schedule

When and what you're measuring — this drives Temporal Alignment and Coverage scoring.

How many distinct measurement timepoints does the study include? *

Count each distinct scheduled assessment (baseline counts as one)

Earliest post-treatment measurement

Latest scheduled measurement

How were measurement timepoints selected?

Based on known biological dynamics of the process being studied Based on standard practice or historical precedent for this indication Based on patient visit schedules or operational convenience Combination of biological rationale and practical constraints Not sure / inherited from earlier protocol version

Specimen types collected (select all that apply) *

Whole BloodCBC, flow cytometry SerumCytokines, proteins PlasmactDNA, cell-free analytes Tissue BiopsyHistology, spatial UrineMetabolomics, biomarkers StoolMicrobiome, calprotectin Nasal / PharyngealPCR, viral load ImagingCT, MRI, PET

Assay categories performed (select all that apply)

Signaling / Phospho-proteinPhospho-flow, Western blot Gene ExpressionRNA-seq, qPCR, spatial tx Cytokine / ChemokineMultiplex panels, ELISA Circulating BiomarkerctDNA, CTC, exosomes Histology / SpatialIHC, mIF, spatial tx Imaging / VolumetricRECIST, volumetric, PET SUV Clinical LabsCBC, CMP, LFTs PK / PharmacokineticsDrug levels, clearance

4Trajectory & Velocity

Individual patient data density and rate-of-change capability — drives Extensibility and Velocity scoring.

How many timepoints per individual patient for the primary biomarker/endpoint?

1–2 timepoints (baseline + endpoint only) 3–4 timepoints 5–6 timepoints 7+ timepoints (dense longitudinal sampling)

Can individual patient trajectories be modeled from the data collected?

No — data is pooled/grouped only Limited — per-patient data exists but insufficient density for curve fitting Yes — sufficient per-patient density for trajectory modeling Yes — with enough density for change-point detection

Does the study capture rate-of-change (velocity) metrics?

No — static thresholds only (e.g. ctDNA detectable vs. undetectable) Basic — two timepoints enabling slope calculation Moderate — multiple timepoints with doubling time or growth rate Strong — dense sampling with explicit velocity endpoints (e.g. ctDNA doubling time predicts outcome)

If rate-of-change metrics are captured, briefly describe

Does the study include an adaptive or interim analysis design?

No Yes — interim analysis for futility/efficacy Yes — adaptive design with protocol modifications based on accumulating data

5Review & Submit

Any additional context and final submission.

What happens next

We'll review your responses and send a preliminary Temporal Readiness Score estimate to your email within 48 hours. This includes a component-level breakdown (Alignment, Coverage, Extensibility, Velocity) and indication-specific benchmarking from our 275,000-trial database. No protocol document is required at this stage.

Additional context or questions (optional)

Data handling

Your responses are stored securely on Scientari's servers and used solely to prepare your Temporal Readiness Assessment. We do not share your information with third parties. No proprietary compound, target, or protocol details are collected by this form. You may request deletion of your data at any time by contacting inquiry@scientari.com.

Assessment Received

Thank you. We'll send your preliminary Temporal Readiness Score to your email within 48 hours, including component-level scoring and indication benchmarks from our 275,000-trial database.