Biology Doesn't Stand Still.
Why Should Your Data?

Welcome to the Fourth Dimension of Biology—where we turn frozen snapshots into dynamic movies.

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The $10 Million Question

Why do 60% of Phase 2 clinical trials fail?

Not because the drug doesn't work. Not because the science is wrong.

Because we're measuring the wrong thing at the wrong time.

❌ What Happens

  • ✓ Drug works at molecular level (hours)
  • ✗ Trials measure tumor size (months)
  • ✗ Connection is missed
  • ✗ Trial fails. $10M evaporates.

✅ The Solution

Measure across all relevant time scales:

  • T0-T1: Drug binding (hours)
  • T2: Gene expression (days)
  • T3: Tissue changes (weeks)
  • T4: Organ response (months)

What If Time Isn't Just a Variable—It's THE Variable?

The Temporal Cascade

T0

Drug Binds

Microseconds to hours. SPR, patch clamp, binding assays.

T2

Genes Activate

Hours to days. RNA-seq, ATAC-seq, metabolomics.

T3

Tissue Remodels

Days to weeks. Spatial transcriptomics, multiplex IF.

T4

Organ Adapts

Weeks to months. Imaging, liquid biopsies, wearables.

The problem: Most studies only measure the last step.

TemporalBio: The Operating System for Time-Aware Biology

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The Temporal Ontology (T0-T6)

"From microseconds to decades—we've mapped all seven time scales of biology"

Our framework organizes every biological process by its natural timescale, from drug binding (T0: microseconds) to population aging (T6: decades).

Explore the Framework →
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The TRS Agent

"Is your study design missing the critical window?"

Our AI agent evaluates temporal readiness before you spend millions on sequencing. Get your study scored (0-40) in minutes, not months.

Try It Free →
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The Diagnostic Toolkit

"Find the 'Goldilocks Zone' where your assay has maximum impact"

Tools to optimize diagnostic timing, measure rate-of-change (not just snapshots), and detect reversible-to-irreversible state transitions.

Learn More →

Test Your Temporal Thinking

Trusted by Researchers Who Think in 4D

"The TRS framework helped us redesign our CAR-T monitoring study. We identified non-responders at Day 7 instead of Week 8. That's a $3M savings in our Phase 2."

— Dr. Sarah Chen
VP of Translational Science, ImmunoTech Therapeutics

"TemporalBio's ontology finally gave us a common language. Our single-cell team, spatial team, and clinicians can actually talk to each other now."

— Prof. James Morrison
Director of Multi-Omics Core, Stanford Medicine

"I used the TRS Agent to optimize my NIH grant. Went from a TRS of 18 to 32 in one revision. The grant got funded."

— Dr. Aisha Patel
Assistant Professor, UCSF

2,000+

Studies Scored

34

Average TRS Improvement

10+

Publications Citing Framework

$50M+

Trial Costs Saved

Get Your Study Scored in 5 Minutes

Try the TRS Agent—free, no signup required. Find out if your temporal design has gaps before you spend a dime on sequencing.

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